The long-term excessive alcohol consumption is associated with heart damage, high blood pressure and stroke, liver damage, cancers of the digestive system, other digestive system disorders, sexual impotence and reduced fertility, increasing risk of breast cancer, sleeping difficulties, brain damage with mood and personality changes and concentration and memory problems. Alcohol can be dangerous when other drugs and medications (including over-the-counter preparations) are taken. Alcohol magnifies the effects of sleeping pills (e.g. Serepax, Valium, Mogadon), cannabis, strong painkillers, some antipsychotics and antidepressants. Effects can be unpredictable when combined with stimulants such as caffeine, cold remedies, appetite suppressants and amphetamines. Oral contraceptive pills or oestrogen replacement therapy can also influence the effects of alcohol.